NSL1

Across TCGA patient cohorts, NSL1 mutation is significantly associated with the RNA expression of many other genes, with 377 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSL1-associated genes across cancer lineages are RNU6-558P, BRK1P1, and RNU6-63P. Each is linked with NSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSL1-to-partner and partner-to-NSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-558P grouped by NSL1-low versus NSL1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSL1→partner) and Y-score (partner→NSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-558P →	+0.455	+4.235	<.001	.001	3	2
SKCM	BRK1P1 →	+0.171	+3.490	.002	.008	3	2
BRCA	RNU6-63P →	+0.357	+4.386	<.001	.008	3	2
SKCM	RNU6-782P →	+0.216	+4.199	<.001	.009	3	2
SKCM	HMGN2P26 →	+0.089	+4.993	<.001	.002	3	2
BRCA	IGHD5-12 →	+1.120	+3.782	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 377 associations by consensus.

RNU6-558P by NSL1 expression — SKCM

Explore this box plot interactively →