NSG2

Across TCGA patient cohorts, NSG2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSG2-associated genes across cancer lineages are EGFR_pY1068, GATA6, and JNK_pT183_Y185. Each is linked with NSG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSG2-to-partner and partner-to-NSG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NSG2-low versus NSG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSG2→partner) and Y-score (partner→NSG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.274	-3.000	.037	.036	3	1
UCEC	GATA6 →	-0.175	-3.162	.039	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.227	-3.308	.010	.010	3	1
UCEC	JNK2 →	+0.281	+2.817	.007	.036	3	1
UCEC	p21 →	+0.229	+3.321	.023	.010	3	1
UCEC	Rab25 →	-0.525	-2.999	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by NSG2 expression — UCEC

Explore this box plot interactively →