NSG1

Across TCGA patient cohorts, NSG1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSG1-associated genes across cancer lineages are eIF4E, ER-alpha_pS118, and MEK1. Each is linked with NSG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSG1-to-partner and partner-to-NSG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NSG1-low versus NSG1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSG1→partner) and Y-score (partner→NSG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.177	+3.013	.037	.018	3	1
UCEC	ER-alpha_pS118 →	-0.305	-2.584	.034	.010	3	1
UCEC	MEK1 →	+0.546	+2.415	<.001	.003	3	1
UCEC	MSH2 →	-0.296	-2.295	.001	.033	3	1
UCEC	mTOR_pS2448 →	-0.159	-3.302	.007	.010	3	1
UCEC	Notch1 →	+0.204	+3.710	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

eIF4E by NSG1 expression — UCEC

Explore this box plot interactively →