Across TCGA pan-cancer cohorts, NSFP1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of NSFP1’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where NSFP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NSFP1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
LUAD, BRCA, and KICH are the cancer types where NSFP1 tumor–normal differential expression is most reproducible.