NSF

Across TCGA patient cohorts, NSF mutation is significantly associated with the RNA expression of many other genes, with 365 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSF-associated genes across cancer lineages are RNY3P11, RNA5SP379, and RN7SL98P. Each is linked with NSF in more than 1 cancer types. Because this analysis shows association rather than direction, both NSF-to-partner and partner-to-NSF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY3P11 grouped by NSF-low versus NSF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSF→partner) and Y-score (partner→NSF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNY3P11 →	+0.184	+2.577	.006	.006	3	2
UCEC	RNA5SP379 →	+0.495	+1.899	<.001	.004	3	2
COAD	RN7SL98P →	+0.268	+5.693	.001	.003	3	2
CESC	RPL12P23 →	+0.164	+3.816	<.001	.007	3	2
CESC	CICP13 →	+0.035	+3.890	<.001	.007	3	1
CESC	RPS26P30 →	+0.158	+5.397	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 365 associations by consensus.

RNY3P11 by NSF expression — UCEC

Explore this box plot interactively →