NSF

Across TCGA patient cohorts, NSF mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSF-associated genes across cancer lineages are HSP70, JNK2, and p27_pT157. Each is linked with NSF in more than 1 cancer types. Because this analysis shows association rather than direction, both NSF-to-partner and partner-to-NSF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by NSF-low versus NSF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSF→partner) and Y-score (partner→NSF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSP70 →	-0.356	-2.700	.049	.006	3	1
UCEC	JNK2 →	+0.274	+3.331	.002	.005	3	1
UCEC	p27_pT157 →	-0.059	-2.000	.022	.032	3	1
UCEC	P-Cadherin →	-0.150	-1.986	.021	.032	3	1
UCEC	Rad50 →	-0.219	-2.000	.045	.032	3	1
UCEC	Rictor_pT1135 →	-0.123	-3.169	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

HSP70 by NSF expression — UCEC

Explore this box plot interactively →