NSF

Across TCGA cell cohorts, NSF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,725 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NSF-associated GO terms across cancer lineages are Negative regulation of beige fat cell differentiation, Cellular response to insulin stimulus, and Positive regulation of cell cycle. Each is linked with NSF in more than 12 cancer types. Because this analysis shows association rather than direction, both NSF-to-partner and partner-to-NSF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of beige fat cell differentiation grouped by NSF-low versus NSF-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NSF→partner) and Y-score (partner→NSF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Negative regulation of beige fat cell differentiation →	+0.117	+0.863	<.001	<.001	3	13
LIVER	Cellular response to insulin stimulus →	+0.044	+0.758	.007	.005	3	12
BLOOD_Myeloma	Positive regulation of cell cycle →	+0.059	+0.946	.004	.005	2	13
SOFT_TISSUE	Cytosolic transport →	+0.062	+0.855	.002	.001	3	11
STOMACH	Phosphatidylinositol-3-phosphate biosynthetic process →	+0.072	+0.799	.003	.006	3	11
STOMACH	Epigenetic regulation of gene expression →	+0.058	+0.850	.004	.009	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,725 associations by consensus.

Negative regulation of beige fat cell differentiation by NSF expression — OESOPHAGUS

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