NSD3

Across TCGA pan-cancer cohorts, NSD3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NSD3 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NSD3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NSD3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where NSD3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.789	0.920	.019	25	view →
CCRCC	DFS	Quartile	III,IV	0.742	0.366	.004	20	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.683	.005	13	view →
LUAD	DFS	Quartile	III,IV	0.993	0.400	.006	12	view →
OV	DFS	Median	All	0.870	1.000	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NSD3–HNSC (OS)

Open the HNSC breakdown →