NSD3

Across TCGA patient cohorts, NSD3 mutation is significantly associated with the RNA expression of many other genes, with 4,618 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSD3-associated genes across cancer lineages are DCP1A, EEF1A1P40, and SKA1. Each is linked with NSD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NSD3-to-partner and partner-to-NSD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCP1A grouped by NSD3-low versus NSD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD3→partner) and Y-score (partner→NSD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCP1A →	+0.323	+1.319	.004	.005	3	3
LIHC	EEF1A1P40 →	+0.103	+4.758	<.001	.006	3	3
UCEC	SKA1 →	+0.508	+1.560	<.001	.001	3	3
UCEC	MPV17L →	-0.609	-2.378	<.001	<.001	3	3
UCEC	SPATA2L →	+0.268	+1.801	.007	.001	3	3
UCEC	NIPA1 →	+0.714	+1.954	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,618 associations by consensus.

DCP1A by NSD3 expression — UCEC

Explore this box plot interactively →