NSD3

Across TCGA patient cohorts, NSD3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSD3-associated genes across cancer lineages are Mre11, eIF4E, and INPP4B. Each is linked with NSD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSD3-to-partner and partner-to-NSD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mre11 grouped by NSD3-low versus NSD3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD3→partner) and Y-score (partner→NSD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	Mre11 →	+0.163	+2.842	.046	.032	3	2
UCEC	eIF4E →	+0.163	+2.428	.005	.001	3	2
UCEC	INPP4B →	-0.291	-2.584	.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.376	-2.137	.002	<.001	3	2
UCEC	ATM →	-0.596	-1.917	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.494	+1.584	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Mre11 by NSD3 expression — CESC

Explore this box plot interactively →