NSD3

Across TCGA cell cohorts, NSD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,331 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NSD3-associated GO terms across cancer lineages are RNA destabilization, Positive regulation of double-strand break repair, and Regulation of nucleotide-excision repair. Each is linked with NSD3 in more than 15 cancer types. Because this analysis shows association rather than direction, both NSD3-to-partner and partner-to-NSD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA destabilization grouped by NSD3-low versus NSD3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD3→partner) and Y-score (partner→NSD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNA destabilization →	+0.053	+0.639	<.001	.001	3	16
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.082	+0.891	<.001	<.001	3	15
LUNG_SCLC	Regulation of nucleotide-excision repair →	+0.101	+0.924	<.001	<.001	3	15
OVARY	Heterochromatin formation →	+0.060	+0.741	.001	<.001	3	15
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.057	+0.750	<.001	.001	3	15
LUNG_NSCLC_LUSC	mRNA destabilization →	+0.057	+1.206	.009	.006	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,331 associations by consensus.

RNA destabilization by NSD3 expression — LARGE_INTESTINE

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