NSD3

Across TCGA cell cohorts, NSD3 mutation is significantly associated with the RNA expression of many other genes, with 146 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NSD3-associated genes across cancer lineages are SPDYE4, FTMT, and SLC2A7. Each is linked with NSD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSD3-to-partner and partner-to-NSD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPDYE4 grouped by NSD3-low versus NSD3-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD3→partner) and Y-score (partner→NSD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPDYE4 →	+0.020	+3.247	<.001	.003	3	2
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1
SOFT_TISSUE	SLC2A7 →	+0.203	+4.222	<.001	.007	3	1
PANCREAS	UGT2B10 →	+0.402	+5.000	<.001	.006	3	1
PANCREAS	NEUROG1 →	+0.043	+5.614	<.001	.002	3	1
CNS	NOBOX →	+0.024	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 146 associations by consensus.

SPDYE4 by NSD3 expression — STOMACH

Explore this box plot interactively →