NSD1

Across TCGA pan-cancer cohorts, NSD1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NSD1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where NSD1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NSD1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

LSCC, HNSC, and LUAD are the cancer types where NSD1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NSD1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.485	<.001	7	view →
HNSC	All	All	−0.288	.007	4	view →
LUAD	All	II,III,IV	+0.246	.002	4	view →
PDAC	Female	All	+0.394	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NSD1–LSCC

Open the LSCC breakdown →