NSD1

Across TCGA patient cohorts, NSD1 mutation is significantly associated with the RNA expression of many other genes, with 10,619 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSD1-associated genes across cancer lineages are C18orf54, C1orf109, and PSAT1. Each is linked with NSD1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NSD1-to-partner and partner-to-NSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf54 grouped by NSD1-low versus NSD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD1→partner) and Y-score (partner→NSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C18orf54 →	+0.359	+1.292	.001	<.001	3	6
LUSC	C1orf109 →	+0.374	+1.859	.004	.005	3	6
HNSC	PSAT1 →	+0.763	+2.494	<.001	<.001	3	6
UCEC	RPL23AP82 →	+0.453	+1.858	<.001	<.001	3	6
HNSC	LSM14B →	+0.400	+1.977	<.001	<.001	3	5
HNSC	HSPA4L →	+0.668	+2.093	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,619 associations by consensus.

C18orf54 by NSD1 expression — UCEC

Explore this box plot interactively →