NSD1

Across TCGA patient cohorts, NSD1 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSD1-associated genes across cancer lineages are Chk1, TAZ, and mTOR. Each is linked with NSD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NSD1-to-partner and partner-to-NSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by NSD1-low versus NSD1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD1→partner) and Y-score (partner→NSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	Chk1 →	+0.292	+2.833	.030	.031	3	5
LUSC	TAZ →	+0.152	+3.018	.004	.017	3	4
HNSC	mTOR →	-0.324	-3.169	.002	.015	3	3
HNSC	ASNS →	+0.392	+1.700	.032	.040	3	3
UCEC	eIF4E →	+0.164	+2.150	.001	<.001	3	3
UCEC	Akt_pT308 →	+0.454	+1.777	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Chk1 by NSD1 expression — CESC

Explore this box plot interactively →