NSD1

Across TCGA cell cohorts, NSD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,465 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NSD1-associated GO terms across cancer lineages are Negative regulation of cell cycle process, mRNA alternative polyadenylation, and mRNA transport. Each is linked with NSD1 in more than 16 cancer types. Because this analysis shows association rather than direction, both NSD1-to-partner and partner-to-NSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by NSD1-low versus NSD1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD1→partner) and Y-score (partner→NSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.075	+0.984	<.001	<.001	3	16
BONE	mRNA alternative polyadenylation →	+0.108	+0.993	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	mRNA transport →	+0.116	+0.957	.001	.002	3	16
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.103	+1.500	<.001	<.001	3	16
BONE	Regulation of mRNA catabolic process →	+0.072	+1.103	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	RNA export from nucleus →	+0.124	+1.072	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,465 associations by consensus.

Negative regulation of cell cycle process by NSD1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →