NSD1

Across TCGA cell cohorts, NSD1 mutation is significantly associated with the RNA expression of many other genes, with 546 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NSD1-associated genes across cancer lineages are IL36A, IL22, and C17orf98. Each is linked with NSD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NSD1-to-partner and partner-to-NSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36A grouped by NSD1-low versus NSD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSD1→partner) and Y-score (partner→NSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL36A →	+0.683	+2.556	<.001	.004	3	3
OVARY	IL22 →	+0.043	+3.181	<.001	.001	3	2
LUNG_NSCLC_LUAD	C17orf98 →	+0.037	+2.560	.004	.006	3	2
LUNG_SCLC	SIGLEC5 →	+0.065	+3.817	<.001	.004	3	2
OVARY	POU1F1 →	+0.348	+2.866	.001	.008	3	2
BLOOD_Lymphoma	CABP5 →	+0.008	+3.452	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 546 associations by consensus.

IL36A by NSD1 expression — BLOOD_Leukemia

Explore this box plot interactively →