NRXN3

Across TCGA patient cohorts, NRXN3 mutation is significantly associated with the RNA expression of many other genes, with 8,236 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRXN3-associated genes across cancer lineages are CENPU, BUB1, and WDHD1. Each is linked with NRXN3 in more than 4 cancer types. Because this analysis shows association rather than direction, both NRXN3-to-partner and partner-to-NRXN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by NRXN3-low versus NRXN3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRXN3→partner) and Y-score (partner→NRXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CENPU →	+0.613	+2.999	<.001	<.001	3	5
STAD	BUB1 →	+0.597	+3.338	.002	.004	3	5
UCEC	WDHD1 →	+0.536	+1.480	<.001	<.001	3	5
STAD	TSPY26P →	-0.899	-2.201	<.001	<.001	3	5
STAD	PPM1G →	+0.394	+1.969	<.001	.007	3	5
STAD	PES1 →	+0.446	+3.823	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,236 associations by consensus.

CENPU by NRXN3 expression — COAD

Explore this box plot interactively →