NRXN3

Across TCGA cell cohorts, NRXN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,211 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NRXN3-associated GO terms across cancer lineages are Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission, Gephyrin clustering involved in postsynaptic density assembly, and Response to UV. Each is linked with NRXN3 in more than 7 cancer types. Because this analysis shows association rather than direction, both NRXN3-to-partner and partner-to-NRXN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission grouped by NRXN3-low versus NRXN3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NRXN3→partner) and Y-score (partner→NRXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission →	+1.475	+2.510	<.001	<.001	3	8
OESOPHAGUS	Gephyrin clustering involved in postsynaptic density assembly →	-0.221	-0.962	.001	.007	3	8
SKIN	Response to UV →	+0.043	+1.382	<.001	.001	3	6
SKIN	Regulation of myoblast fusion →	+0.075	+1.395	<.001	.003	3	6
SOFT_TISSUE	Regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway →	+0.120	+1.267	<.001	.004	3	6
SOFT_TISSUE	Regulation of ubiquitin-dependent protein catabolic process →	+0.036	+1.452	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,211 associations by consensus.

Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission by NRXN3 expression — LIVER

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