NRXN3

Across TCGA cell cohorts, NRXN3 mutation is significantly associated with the RNA expression of many other genes, with 630 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRXN3-associated genes across cancer lineages are GKN2, C20orf85, and CCDC9B. Each is linked with NRXN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRXN3-to-partner and partner-to-NRXN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GKN2 grouped by NRXN3-low versus NRXN3-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRXN3→partner) and Y-score (partner→NRXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GKN2 →	+0.372	+4.017	.004	.007	3	2
LUNG_SCLC	C20orf85 →	+0.436	+2.032	.006	.006	3	2
LUNG_SCLC	CCDC9B →	-1.278	-3.459	.007	.002	3	2
BLOOD_Leukemia	MRPS15 →	+0.528	+3.199	<.001	.007	3	2
LARGE_INTESTINE	CLUAP1 →	+0.603	+3.404	<.001	<.001	3	2
LARGE_INTESTINE	ZNF330 →	+0.445	+2.364	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 630 associations by consensus.

GKN2 by NRXN3 expression — OESOPHAGUS

Explore this box plot interactively →