NRXN2

Across TCGA patient cohorts, NRXN2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,893 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NRXN2-associated genes across cancer lineages are YPEL1, SNRPD3, and PRODH. Each is linked with NRXN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRXN2-to-partner and partner-to-NRXN2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NRXN2 versus YPEL1 in GBM, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRXN2→partner) and Y-score (partner→NRXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	YPEL1 →	+0.569	+0.532	.001	<.001	3	1
GBM	SNRPD3 →	+0.357	+0.410	<.001	<.001	3	1
GBM	PRODH →	+0.981	+0.573	<.001	<.001	3	1
GBM	GRK3 →	+0.634	+0.550	<.001	<.001	3	1
GBM	SEZ6L →	+1.723	+0.570	<.001	<.001	3	1
GBM	LGALS1 →	-0.606	-0.510	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,893 associations by consensus.

NRXN2 vs YPEL1 — GBM

Explore this scatter interactively →