NRXN2

Across TCGA patient cohorts, NRXN2 mutation is significantly associated with the RNA expression of many other genes, with 7,475 significant associations in total. STAD shows the largest number of these associations.

The most reproducible NRXN2-associated genes across cancer lineages are CHEK1, ENO1, and PARP2. Each is linked with NRXN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both NRXN2-to-partner and partner-to-NRXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by NRXN2-low versus NRXN2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRXN2→partner) and Y-score (partner→NRXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CHEK1 →	+0.572	+1.800	.005	.008	2	6
LUAD	ENO1 →	+0.440	+2.181	.005	.002	3	5
UCEC	PARP2 →	+0.271	+1.402	.005	.008	3	5
COAD	STIL →	+0.545	+2.472	<.001	<.001	3	5
COAD	SMC2 →	+0.585	+3.625	<.001	.001	3	5
COAD	SASS6 →	+0.500	+1.775	<.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,475 associations by consensus.

CHEK1 by NRXN2 expression — LUAD

Explore this box plot interactively →