NRXN2

Across TCGA cell cohorts, NRXN2 mutation is significantly associated with the RNA expression of many other genes, with 790 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRXN2-associated genes across cancer lineages are MDH1B, IGFL3, and OR51B2. Each is linked with NRXN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NRXN2-to-partner and partner-to-NRXN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MDH1B grouped by NRXN2-low versus NRXN2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRXN2→partner) and Y-score (partner→NRXN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MDH1B →	+0.514	+3.318	<.001	.005	3	3
STOMACH	IGFL3 →	+0.392	+3.009	<.001	.004	3	2
STOMACH	OR51B2 →	+0.782	+3.857	<.001	.001	3	2
BREAST	ASB11 →	+0.008	+2.554	.008	.005	3	2
BLOOD_Lymphoma	GBA3 →	+0.964	+3.341	.008	.009	3	2
CNS	DPRX →	+0.050	+4.321	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 790 associations by consensus.

MDH1B by NRXN2 expression — BLOOD_Leukemia

Explore this box plot interactively →