NRXN1

Across TCGA pan-cancer cohorts, NRXN1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated NRXN1 data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NRXN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NRXN1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and STAD show a favorable association.

KIRC, ACC, and UVM are the cancer types where NRXN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.054	0.881	<.001	48	view →
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
UVM	OS	Median	II,III,IV	0.213	0.718	.002	27	view →
SKCM	DFS	Median	II,III,IV	0.850	0.630	.001	17	view →
STAD	OS	Median	III,IV	0.786	0.350	.022	10	view →
THCA	OS	Median	All	0.323	0.955	<.001	8	view →
OV	DFS	Median	III,IV	0.780	0.366	.032	6	view →
SCLC	OS	Median	IV	0.829	0.241	.005	6	view →
UCEC	DFS	Median	All	0.780	0.621	.035	6	view →
ESCA	OS	Median	III,IV	0.112	0.573	<.001	6	view →
KIRP	DFS	Median	All	0.858	0.918	.017	5	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

NRXN1–KIRC (OS)

Open the KIRC breakdown →