NRXN1

Across TCGA cell cohorts, NRXN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,329 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NRXN1-associated GO terms across cancer lineages are Regulation of microtubule-based process, Regulation of microtubule polymerization, and Protein localization to nucleus. Each is linked with NRXN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both NRXN1-to-partner and partner-to-NRXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of microtubule-based process grouped by NRXN1-low versus NRXN1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NRXN1→partner) and Y-score (partner→NRXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of microtubule-based process →	+0.056	+2.147	.002	<.001	3	6
LUNG_SCLC	Regulation of microtubule polymerization →	+0.100	+2.069	.002	<.001	3	6
LARGE_INTESTINE	Protein localization to nucleus →	+0.030	+0.049	.001	.004	2	6
BLOOD_Myeloma	Positive regulation of fibroblast growth factor receptor signaling pathway →	-0.176	-0.955	.002	.004	3	5
SKIN	Positive regulation of synapse maturation →	-0.224	-0.355	<.001	.007	3	5
LUNG_SCLC	Regulation of neuromuscular synaptic transmission →	+1.520	+2.588	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,329 associations by consensus.

Regulation of microtubule-based process by NRXN1 expression — LUNG_SCLC

Explore this box plot interactively →