NRXN1

Across TCGA cell cohorts, NRXN1 mutation is significantly associated with the RNA expression of many other genes, with 903 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRXN1-associated genes across cancer lineages are ORC2, FADS6, and RWDD3. Each is linked with NRXN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NRXN1-to-partner and partner-to-NRXN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ORC2 grouped by NRXN1-low versus NRXN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRXN1→partner) and Y-score (partner→NRXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ORC2 →	+0.363	+1.932	.004	.002	3	3
BLOOD_Lymphoma	FADS6 →	+0.019	+2.428	.002	.005	3	2
LUNG_NSCLC_LUAD	RWDD3 →	+0.496	+2.459	.006	.005	3	2
LUNG_NSCLC_LUAD	PRPF38B →	+0.382	+3.459	.003	.001	3	2
LUNG_NSCLC_LUAD	PSRC1 →	+0.654	+1.807	<.001	.007	3	2
LUNG_NSCLC_LUAD	NUSAP1 →	+0.439	+1.802	.007	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 903 associations by consensus.

ORC2 by NRXN1 expression — LARGE_INTESTINE

Explore this box plot interactively →