NRTN

Across TCGA pan-cancer cohorts, NRTN RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NRTN data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher NRTN RNA is associated with better overall survival. In most high-consensus cancer types, elevated NRTN expression acts as an unfavorable survival marker, although some lineages such as UVM and HNSC show a favorable association.

UVM, HNSC, and KIRC are the cancer types where NRTN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.787	0.350	<.001	146	view →
HNSC	OS	Tertile	All	0.817	0.686	<.001	106	view →
KIRC	DFS	Quartile	All	0.661	0.285	<.001	104	view →
LUSC	OS	Median	II,III,IV	0.737	0.517	<.001	71	view →
UCEC	DFS	Quartile	All	0.835	0.630	<.001	48	view →
COAD	DFS	Median	All	0.427	0.681	.002	30	view →
THYM	DFS	Median	All	0.900	0.633	<.001	29	view →
LGG	OS	Median	All	0.937	0.848	<.001	19	view →
THCA	DFS	Quartile	III,IV	0.552	0.871	.007	15	view →
ESCA	DFS	Median	II,III,IV	0.293	1.000	.002	14	view →
BLCA	DFS	Quartile	III,IV	0.152	0.450	.007	14	view →
UCS	DFS	Tertile	IV	0.323	0.978	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NRTN–UVM (OS)

Open the UVM breakdown →