NRSN2

Across TCGA patient cohorts, NRSN2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRSN2-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK_pT183_Y185, and PDCD4. Each is linked with NRSN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRSN2-to-partner and partner-to-NRSN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by NRSN2-low versus NRSN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRSN2→partner) and Y-score (partner→NRSN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.123	-3.160	.041	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.167	-3.169	.040	.019	3	1
UCEC	PDCD4 →	-0.595	-2.459	.008	.020	3	1
UCEC	Annexin-1 →	+0.562	+3.584	.027	.002	3	1
UCEC	ARID1A →	-0.273	-2.314	.002	.035	3	1
UCEC	XBP1 →	-0.208	-2.459	.002	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FOXO3a_pS318_S321 by NRSN2 expression — UCEC

Explore this box plot interactively →