NRP2

Across TCGA pan-cancer cohorts, NRP2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NRP2 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NRP2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NRP2 expression acts as an unfavorable survival marker.

HNSC, LUAD, and PDAC are the cancer types where NRP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.624	0.811	.022	7	view →
LUAD	OS	Tertile	II,III,IV	0.510	1.000	.040	3	view →
PDAC	DFS	Quartile	II,III,IV	0.272	0.470	.016	3	view →
CCRCC	OS	Quartile	III,IV	0.517	0.833	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NRP2–HNSC (OS)

Open the HNSC breakdown →