NRP2

Across TCGA patient cohorts, NRP2 mutation is significantly associated with the RNA expression of many other genes, with 5,278 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRP2-associated genes across cancer lineages are CORO2B, ADGRD1, and IDUA. Each is linked with NRP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NRP2-to-partner and partner-to-NRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CORO2B grouped by NRP2-low versus NRP2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRP2→partner) and Y-score (partner→NRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CORO2B →	-1.480	-1.800	<.001	.004	3	4
UCEC	ADGRD1 →	-0.247	-1.866	.002	<.001	3	4
UCEC	IDUA →	-0.465	-1.243	<.001	<.001	3	4
UCEC	CCNB1 →	+0.572	+1.584	<.001	<.001	3	4
UCEC	RNFT2 →	+0.296	+1.557	.005	<.001	3	4
UCEC	ERP27 →	-0.991	-1.456	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,278 associations by consensus.

CORO2B by NRP2 expression — SKCM

Explore this box plot interactively →