NRP2

Across TCGA patient cohorts, NRP2 mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRP2-associated genes across cancer lineages are c-Kit, eEF2, and INPP4B. Each is linked with NRP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NRP2-to-partner and partner-to-NRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by NRP2-low versus NRP2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRP2→partner) and Y-score (partner→NRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	c-Kit →	-0.537	-3.169	.031	.019	3	4
UCEC	eEF2 →	+0.266	+1.362	.003	.031	3	4
COAD	INPP4B →	-0.384	-3.000	.017	.034	3	4
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.471	+1.700	.022	.040	3	3
COAD	GAPDH →	+0.808	+1.749	<.001	.049	3	3
UCEC	S6_pS240_S244 →	+0.210	+0.917	.041	.025	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

c-Kit by NRP2 expression — LUAD

Explore this box plot interactively →