NRP2

Across TCGA cell cohorts, NRP2 mutation is significantly associated with the RNA expression of many other genes, with 109 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRP2-associated genes across cancer lineages are OR4F21, DMRTC2, and HABP2. Each is linked with NRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRP2-to-partner and partner-to-NRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F21 grouped by NRP2-low versus NRP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRP2→partner) and Y-score (partner→NRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F21 →	+0.119	+2.041	<.001	.007	3	2
BLOOD_Leukemia	DMRTC2 →	+0.036	+4.539	<.001	.007	3	2
SKIN	HABP2 →	+0.158	+3.451	<.001	.008	3	2
SOFT_TISSUE	OR2M5 →	+0.017	+4.369	<.001	.008	3	1
SOFT_TISSUE	SLCO1B7 →	+0.221	+4.417	<.001	.004	3	1
SOFT_TISSUE	TCP11X2 →	+0.010	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 109 associations by consensus.

OR4F21 by NRP2 expression — LARGE_INTESTINE

Explore this box plot interactively →