NRP1

Across TCGA pan-cancer cohorts, NRP1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NRP1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where NRP1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NRP1 is over-expressed in tumor, although a few such as LSCC and COAD show the opposite, repressed pattern.

CCRCC, LSCC, and PDAC are the cancer types where NRP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	All	+0.398	<.001	10	view →
LSCC	Female	All	−0.704	<.001	8	view →
PDAC	Male	All	+0.422	<.001	6	view →
COAD	Female	All	−0.309	<.001	6	view →
HNSC	Male	III,IV	−0.236	<.001	6	view →
LUAD	All	II,III,IV	−0.196	<.001	5	view →
OV	All	All	−0.906	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

NRP1–CCRCC

Open the CCRCC breakdown →