NRN1

Across TCGA patient cohorts, NRN1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,527 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NRN1-associated genes across cancer lineages are PRODH, CARD10, and SEZ6L. Each is linked with NRN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRN1-to-partner and partner-to-NRN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NRN1 versus PRODH in GBM, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRN1→partner) and Y-score (partner→NRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+0.730	+0.636	<.001	<.001	3	1
GBM	CARD10 →	+0.297	+0.555	.002	<.001	3	1
GBM	SEZ6L →	+1.095	+0.442	.003	.006	3	1
GBM	SEPTIN3 →	+1.284	+0.951	<.001	<.001	3	1
GBM	RASL10A →	+0.599	+0.563	.001	<.001	3	1
GBM	NEFH →	+1.259	+0.813	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,527 associations by consensus.

NRN1 vs PRODH — GBM

Explore this scatter interactively →