NRN1

Across TCGA patient cohorts, NRN1 mutation is significantly associated with the RNA expression of many other genes, with 1,182 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRN1-associated genes across cancer lineages are MIR4445, MTND2P33, and SSRP1. Each is linked with NRN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRN1-to-partner and partner-to-NRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4445 grouped by NRN1-low versus NRN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRN1→partner) and Y-score (partner→NRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4445 →	+0.189	+4.571	<.001	.002	3	2
SKCM	MTND2P33 →	+0.036	+3.953	.004	.005	3	2
UCEC	SSRP1 →	+0.515	+3.354	.009	.005	3	1
UCEC	COX15 →	+0.474	+3.592	.002	.001	3	1
UCEC	INTS4 →	+0.355	+2.939	.006	<.001	3	1
UCEC	LAMTOR1 →	+0.357	+4.010	.008	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,182 associations by consensus.

MIR4445 by NRN1 expression — UCEC

Explore this box plot interactively →