NRN1

Across TCGA patient cohorts, NRN1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRN1-associated genes across cancer lineages are PCNA, SLC1A5, and eEF2. Each is linked with NRN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRN1-to-partner and partner-to-NRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NRN1-low versus NRN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRN1→partner) and Y-score (partner→NRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.322	+2.999	.001	.035	3	2
UCEC	SLC1A5 →	-0.414	-2.452	.044	.020	3	2
UCEC	eEF2 →	+0.454	+2.999	.006	.035	3	1
UCEC	eIF4E →	+0.195	+2.584	.047	.011	3	1
UCEC	MEK1 →	+0.391	+3.169	.021	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.200	+1.887	.038	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PCNA by NRN1 expression — UCEC

Explore this box plot interactively →