NRN1

Across TCGA cell cohorts, NRN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,326 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NRN1-associated GO terms across cancer lineages are Proton motive force-driven ATP synthesis, Purine ribonucleoside triphosphate metabolic process, and Positive regulation of mRNA metabolic process. Each is linked with NRN1 in more than 6 cancer types. Because this analysis shows association rather than direction, both NRN1-to-partner and partner-to-NRN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proton motive force-driven ATP synthesis grouped by NRN1-low versus NRN1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NRN1→partner) and Y-score (partner→NRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Proton motive force-driven ATP synthesis →	+0.087	+1.497	<.001	.001	3	7
BONE	Purine ribonucleoside triphosphate metabolic process →	+0.065	+1.787	.004	.007	3	7
LUNG_NSCLC_LUSC	Positive regulation of mRNA metabolic process →	+0.063	+1.713	<.001	.002	3	6
LUNG_NSCLC_LUSC	Regulation of RNA stability →	+0.060	+1.935	<.001	<.001	3	6
LUNG_NSCLC_LUSC	Regulation of mRNA stability →	+0.057	+1.935	<.001	<.001	3	6
BREAST	Cell cycle phase transition →	+0.064	+1.763	.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,326 associations by consensus.

Proton motive force-driven ATP synthesis by NRN1 expression — OVARY

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