NRM

Across TCGA pan-cancer cohorts, NRM mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NRM data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NRM mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NRM expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where NRM mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.286	0.475	.005	29	view →
UCEC	DFS	Median	All	0.841	0.967	.004	26	view →
HNSC	DFS	Quartile	III,IV	1.000	0.874	.029	3	view →
CCRCC	OS	Median	All	0.915	0.753	.039	1	view →
LUAD	OS	Quartile	II,III,IV	0.861	1.000	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NRM–PDAC (DFS)

Open the PDAC breakdown →