NRM

Across TCGA patient cohorts, NRM protein abundance is significantly associated with the RNA expression of many other genes, with 9,054 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRM-associated genes across cancer lineages are TET1, GPR161, and S1PR3. Each is linked with NRM in more than 3 cancer types. Because this analysis shows association rather than direction, both NRM-to-partner and partner-to-NRM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NRM versus TET1 in GBM, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRM→partner) and Y-score (partner→NRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TET1 →	+0.711	+0.451	<.001	.006	3	4
UCEC	GPR161 →	+0.830	+0.464	.002	.006	3	4
CCRCC	S1PR3 →	+0.751	+0.280	<.001	<.001	3	4
LSCC	TRO →	+0.690	+0.316	.001	.001	3	4
OV	GLIS2 →	+1.129	+0.328	.003	.008	3	4
HNSC	C2orf68 →	+0.642	+0.363	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,054 associations by consensus.

NRM vs TET1 — GBM

Explore this scatter interactively →