NRM

Across TCGA patient cohorts, NRM mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRM-associated genes across cancer lineages are Monocytes, Basophils, and Myocytes. Each is linked with NRM in more than 1 cancer types. Because this analysis shows association rather than direction, both NRM-to-partner and partner-to-NRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Monocytes grouped by NRM-low versus NRM-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRM→partner) and Y-score (partner→NRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Monocytes →	+0.014	+5.225	<.001	.034	3	1
UCEC	Basophils →	+0.193	+3.169	.038	.020	3	1
UCEC	Myocytes →	+0.045	+3.212	.012	.010	1	2
UCEC	pDC →	+0.057	+2.815	.032	.036	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Monocytes by NRM expression — SKCM

Explore this box plot interactively →