NRK

Across TCGA pan-cancer cohorts, NRK mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NRK data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NRK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NRK expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where NRK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.623	0.956	.010	17	view →
PDAC	OS	Quartile	All	0.975	0.237	.007	13	view →
CCRCC	DFS	Median	II,III,IV	0.476	0.737	.040	2	view →
LUAD	DFS	Median	All	0.572	0.824	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NRK–HNSC (DFS)

Open the HNSC breakdown →