NRK

Across TCGA patient cohorts, NRK mutation is significantly associated with the RNA expression of many other genes, with 5,153 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRK-associated genes across cancer lineages are SORCS2, NDUFB6, and PBK. Each is linked with NRK in more than 5 cancer types. Because this analysis shows association rather than direction, both NRK-to-partner and partner-to-NRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SORCS2 grouped by NRK-low versus NRK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRK→partner) and Y-score (partner→NRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SORCS2 →	-0.460	-1.461	<.001	<.001	3	6
UCEC	NDUFB6 →	+0.349	+1.297	<.001	<.001	3	4
STAD	PBK →	+0.909	+2.824	.002	.001	3	4
UCEC	CENPU →	+0.510	+1.329	<.001	<.001	3	4
UCEC	CHAF1B →	+0.468	+1.214	<.001	<.001	3	4
UCEC	H2AZ1 →	+0.521	+1.884	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,153 associations by consensus.

SORCS2 by NRK expression — UCEC

Explore this box plot interactively →