NRK

Across TCGA patient cohorts, NRK mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRK-associated genes across cancer lineages are ASNS, 4E-BP1, and Smad1. Each is linked with NRK in more than 4 cancer types. Because this analysis shows association rather than direction, both NRK-to-partner and partner-to-NRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by NRK-low versus NRK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRK→partner) and Y-score (partner→NRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.208	+0.725	.010	.035	3	5
COAD	4E-BP1 →	+0.341	+3.321	<.001	.009	3	5
LUAD	Smad1 →	+0.224	+2.819	<.001	.035	2	5
STAD	FoxM1 →	+0.254	+2.700	.017	.005	3	4
COAD	14-3-3_beta →	-0.238	-2.674	.004	.006	3	3
LUSC	p27 →	-0.146	-1.691	.015	.043	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

ASNS by NRK expression — UCEC

Explore this box plot interactively →