NRK

Across TCGA cell cohorts, NRK mutation is significantly associated with the RNA expression of many other genes, with 487 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRK-associated genes across cancer lineages are GPR63, ARHGEF4, and DNAAF3. Each is linked with NRK in more than 2 cancer types. Because this analysis shows association rather than direction, both NRK-to-partner and partner-to-NRK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR63 grouped by NRK-low versus NRK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRK→partner) and Y-score (partner→NRK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GPR63 →	+0.961	+3.115	.002	.009	3	3
BLOOD_Leukemia	ARHGEF4 →	+0.616	+3.489	.003	.001	3	3
LUNG_NSCLC_LUAD	DNAAF3 →	+1.115	+3.206	.001	.006	3	2
LUNG_NSCLC_LUAD	OR56A1 →	+0.202	+3.019	<.001	.001	3	2
BLOOD_Leukemia	CYP39A1 →	+0.099	+2.769	<.001	<.001	3	2
BLOOD_Leukemia	EDA →	+0.890	+2.510	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 487 associations by consensus.

GPR63 by NRK expression — BLOOD_Leukemia

Explore this box plot interactively →