NRIP3

Across TCGA pan-cancer cohorts, NRIP3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NRIP3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NRIP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NRIP3 is over-expressed in tumor, although a few such as KIRP and UCEC show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where NRIP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRIP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.803	<.001	12	view →
COAD	All	II,III,IV	+0.450	<.001	11	view →
LUAD	Male	All	+1.295	<.001	9	view →
KICH	Female	II,III,IV	+3.234	<.001	8	view →
LUSC	Female	All	+1.608	<.001	8	view →
LIHC	All	II,III,IV	+0.204	<.001	7	view →
KIRP	Male	II,III,IV	−0.636	<.001	6	view →
BRCA	All	II,III,IV	+0.646	.008	4	view →
UCEC	All	All	−0.576	.014	2	view →
CHOL	Female	All	+0.500	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NRIP3–HNSC

Open the HNSC breakdown →