NRG4

Across TCGA patient cohorts, NRG4 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NRG4-associated genes across cancer lineages are RNU1-68P, C7orf77, and RNA5SP412. Each is linked with NRG4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRG4-to-partner and partner-to-NRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-68P grouped by NRG4-low versus NRG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG4→partner) and Y-score (partner→NRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU1-68P →	+0.126	+4.292	<.001	.006	3	1
UCEC	C7orf77 →	+0.141	+3.134	<.001	.005	3	1
UCEC	RNA5SP412 →	+0.686	+2.967	.003	.007	3	1
HNSC	RNU6-949P →	+0.394	+6.221	<.001	.001	3	1
HNSC	MIR578 →	+0.570	+5.069	<.001	.008	3	1
HNSC	TXNL4AP1 →	+0.092	+5.069	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

RNU1-68P by NRG4 expression — UCEC

Explore this box plot interactively →