NRG4

Across TCGA cell cohorts, NRG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,826 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible NRG4-associated GO terms across cancer lineages are Negative regulation of mRNA catabolic process, Negative regulation of RNA catabolic process, and mRNA splice site recognition. Each is linked with NRG4 in more than 10 cancer types. Because this analysis shows association rather than direction, both NRG4-to-partner and partner-to-NRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA catabolic process grouped by NRG4-low versus NRG4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG4→partner) and Y-score (partner→NRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of mRNA catabolic process →	+0.062	+1.725	<.001	<.001	3	11
OESOPHAGUS	Negative regulation of RNA catabolic process →	+0.078	+2.427	.001	<.001	3	11
LARGE_INTESTINE	mRNA splice site recognition →	+0.105	+0.472	<.001	<.001	3	9
OESOPHAGUS	Spliceosomal complex assembly →	+0.109	+1.954	.008	.006	3	9
BONE	Negative regulation of gene expression, epigenetic →	+0.063	+0.771	<.001	<.001	3	9
BONE	Regulation of mRNA splicing, via spliceosome →	+0.077	+0.639	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,826 associations by consensus.

Negative regulation of mRNA catabolic process by NRG4 expression — OVARY

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