NRG2

Across TCGA cell cohorts, NRG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,005 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NRG2-associated GO terms across cancer lineages are Regulation of heart rate by cardiac conduction, Regulation of actin filament-based movement, and Regulation of cardiac muscle cell contraction. Each is linked with NRG2 in more than 10 cancer types. Because this analysis shows association rather than direction, both NRG2-to-partner and partner-to-NRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of heart rate by cardiac conduction grouped by NRG2-low versus NRG2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG2→partner) and Y-score (partner→NRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of heart rate by cardiac conduction →	-0.227	-0.671	.006	.005	3	11
LUNG_NSCLC_LUAD	Regulation of actin filament-based movement →	-0.181	-0.864	<.001	<.001	3	11
URINARY_TRACT	Regulation of cardiac muscle cell contraction →	-0.160	-0.953	<.001	.002	3	11
STOMACH	Bundle of His cell to Purkinje myocyte communication →	-0.250	-0.657	<.001	.008	3	9
KIDNEY	Negative regulation of post-translational protein modification →	+0.074	+0.857	.001	.008	3	9
STOMACH	Cardiac conduction →	-0.220	-1.282	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,005 associations by consensus.

Regulation of heart rate by cardiac conduction by NRG2 expression — OESOPHAGUS

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