NRG2

Across TCGA cell cohorts, NRG2 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NRG2-associated genes across cancer lineages are CENPVL3, WFDC10A, and PRR23C. Each is linked with NRG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRG2-to-partner and partner-to-NRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPVL3 grouped by NRG2-low versus NRG2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRG2→partner) and Y-score (partner→NRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CENPVL3 →	+0.703	+4.906	<.001	.006	3	1
SOFT_TISSUE	WFDC10A →	+0.069	+4.369	<.001	.008	3	1
SOFT_TISSUE	PRR23C →	+0.005	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR4A47 →	+0.014	+4.369	<.001	.008	3	1
BLOOD_Leukemia	PRMT8 →	+0.573	+4.409	<.001	.005	3	1
BLOOD_Leukemia	PAX1 →	+0.053	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

CENPVL3 by NRG2 expression — OESOPHAGUS

Explore this box plot interactively →