NRG1

Across TCGA pan-cancer cohorts, NRG1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NRG1 data layer compared with 25 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NRG1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NRG1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC and LSCC are the cancer types where NRG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.514	0.816	.001	35	view →
LSCC	DFS	Median	III,IV	0.820	0.465	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

NRG1–HNSC (OS)

Open the HNSC breakdown →